Epidermal Growth Factor Concentrations in Seminal Plasma from Patients with Hypogonadism – Changes after Hormone Replacement
作者:
Hideki Fuse,
Masaou Okumura,
Mamoru Sakamoto,
Taizo Kazama,
Takashi Katayama,
期刊:
Urologia Internationalis
(Karger Available online 1994)
卷期:
Volume 52,
issue 1
页码: 9-13
ISSN:0042-1138
年代: 1994
DOI:10.1159/000282561
出版商: S. Karger AG
关键词: Epidermal growth factor;Seminal plasma;Hypogonadism;Hormone replacement
数据来源: Karger
摘要:
Epidermal growth factor (EGF) content in seminal plasma of 17 patients with androgen deficiency (12 Klinefelter’s syndrome and 5 hypogonadotropic hypogonadism) was determined before and after hormone replacement. No significant increase of plasma testosterone level was demonstrated after testosterone administration in Klinefelter’s syndrome, although the level in 4 of 5 patients with hypogonadotropic hypogonadism reached the normal range. In 16 patients, except 1 with hypogonadotropic hypogonadism with no increase of blood testosterone level, prostate volume increased after hormone therapy, and volumes after treatment were significantly larger than those before treatment. On the other hand, EGF concentration in seminal plasma remained at the pretreatment level in most patients. It is therefore concluded that although the prostate volume increases to almost normal after treatment, prostate function does not improve in most patients, indicating that in patients with hypogonadotropic hypogonadism fertility potential may remain low, even if they obtain normal seminal parameters after treatm
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