Exhaled Nitric Oxide Levels in Childhood AsthmaA More Reliable Indicator of Asthma Severity than Lung Function Measurement?
作者:
Giorgio L. Piacentini,
Ylenia Suzuki,
Alessandro Bodini,
期刊:
BioDrugs
(ADIS Available online 2000)
卷期:
Volume 13,
issue 4
页码: 279-288
ISSN:1173-8804
年代: 2000
出版商: ADIS
关键词: Asthma, assessment;Asthma, pathogenesis;Children;Pulmonary function tests
数据来源: ADIS
摘要:
The level of exhaled nitric oxide (NO) has been demonstrated to reflect the degree of airway inflammation in patients with asthma and to be related to the severity of asthma, as well as to the efficacy of treatment. In contrast, lung function tests provide information about airway volumes and flows reflecting the level of airway obstruction, but do not allow any direct information about the degree of airway inflammation.Several studies have evaluated the relationships between the level of airway inflammation assessed by exhaled NO and the levels of airway obstruction and/or bronchial hyperresponsiveness in asthmatic adults and children.These studies highlight the complex pathophysiology of asthma and suggest that exhaled NO may have a promising role in addition to lung function measurement in the evaluation of asthma severity in children.
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