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Heteroaromatic Nucleophilic Substitution Reactions by Phase‐Transfer Catalysis– Synthesis of New Alkoxypridazin‐3(2H)‐ones

 

作者: M. Carmen Gómez‐Gil,   Vicente Gómez‐Parra,   Félix Sánchez,   TomáS Torres,  

 

期刊: Liebigs Annalen der Chemie  （WILEY Available online 1985）
卷期: Volume 1985, issue 7  

页码: 1465-1473

 

ISSN:0170-2041

 

年代: 1985

 

DOI:10.1002/jlac.198519850717

 

出版商: WILEY‐VCH Verlag

 

数据来源: WILEY

 

摘要:

AbstractThe synthesis of several 4‐ and 5‐alkoxy‐substituted pyridazin‐3(2H)‐ones with hypotensive and β‐blocking activities by phase‐transfer catalysis (PTC) starting from halopyridazin‐3(2H)‐ones is described. The nucleophilic displacement reaction proceeds easily at the 5‐position and remarkably slower at the 4‐position. In the case of 4,5‐dihalopyridazin‐3(2H)‐ones the PTC methods provide a high regioselectivity toward

 

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