The prognostic significance of radiological and symptomatic bone involvement in childhood acute lymphoblastic leukaemia
作者:
Ian M. Hann,
Subash Gupta,
Michael K. Palmer,
Patricia H. Morris‐Jones,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1979)
卷期:
Volume 6,
issue 1
页码: 51-55
ISSN:0098-1532
年代: 1979
DOI:10.1002/mpo.2950060108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: acute lymphoblastic leukaemia;children;bone;prognosis
数据来源: WILEY
摘要:
AbstractFull skeletal survey was performed on 193 consecutive children presenting over a 6‐year period with acute lymphoblastic leukaemia (ALL). A record was made of the degree of bone pain in these patients and 60 others presenting immediately prior to the availability of skeletal surveys. Bone pain was present in 76 out of 253 patients (30%) and radiological bone changes characteristic of leukaemia in 125 out of 193 (65%). A significant correlation was found between the severity of bone pain and the number of bones involved on × ray (r = 0.25, P =<0.001), but not between initial white cell counts and bone score (r =‐0.14, P = 0.08). There was no significant correlation between the degree of bone pain and survival or length of first remission (P = 0.29 and 0.86). Similarly, the extent of radiological bone disease was of no prognostic significance with relation to survival (P = 0.41) or length of first remission (P = 0
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