Impact of combined modality therapy on the treatment of adenocarcinoma of the colon
作者:
Marshall R. Posner,
Ronald Bleday,
Mark Huberman,
John M. Jessup,
Paul Busse,
Glenn Steele,
期刊:
Seminars in Surgical Oncology
(WILEY Available online 1993)
卷期:
Volume 9,
issue 1
页码: 33-38
ISSN:8756-0437
年代: 1993
DOI:10.1002/ssu.2980090107
出版商: John Wiley&Sons, Inc.
关键词: colonic neoplasms;adjuvant therapy;prognosis;chemotherapy
数据来源: WILEY
摘要:
AbstractAn emphasis on careful surgical staging of adenocarcinoma of the colon has improved the predictive value of tumor staging systems. As a result of improved staging and carefully conducted randomized clinical trials, adjuvant therapy of locally advanced colon cancer, based on 5‐fluorouracil chemotherapy, has been proven to substantially reduce recurrence rates and significantly increase overall survival for selected patients. Improved treatments and schedules are currently being studied in randomized trials and may increase the efficacy of this adjuvant therapy. Radiation therapy has not as yet been integrated into the adjuvant treatment of colon carcinoma. The application of a combined approach of surgery and chemotherapy in selected patients with liver metastases may also improve cure rates and long‐term survival. The developing understanding of molecular determinants for the biological behavior of these cancers will increase the opportunities to identify, on the one hand, those patients who will benefit from specific therapies, and, on the other hand, new therapeutic strategies and treatme
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