Hypercalcemia and Nephrolithiasis Provoked by Serum Phosphorus Reduction in a Patient with Chronic Renal Failure and Sarcoidosis
作者:
Ralph J. Caruana,
Robert S. Weinstein,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 4
页码: 271-273
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182967
出版商: S. Karger AG
关键词: Sarcoidosis;Hypercalcemia;Vitamin D
数据来源: Karger
摘要:
A patient with sarcoidosis and chronic renal failure was treated for hyperphosphatemia with aluminum hydroxide. The subsequent fall in serum phosphorus was followed by the development of hypercalcemia and nephrolithiasis. Corticosteroid therapy normalized the serum calcium and halted the progression of the nephrolithiasis, but did not improve renal function. Hyperphosphatemia may have blocked the expression of sarcoid hypercalcemia in the patient. The mechanism is unclear but inhibition of the synthesis or action of 1,25-dihydroxyvitamin D may have been involved. Reduction of serum phosphorus may lead to severe hypercalcemia in some patients with sarcoidosis.
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