Background: Doxorubicin and ifosfamide are the most active drugs in the treatment of adult advanced soft tissue sarcoma. For patients not or no longer responding to these cytostatic agents no widely accepted salvage chemotherapy is known. Patients and Methods: Between 1986 and 1995 100 adult patients with advanced soft tissue sarcoma were treated with a combination of doxorubicin and ifosfamide. After transient response or primary failure to this combination, salvage chemotherapy was administered to 22 patients. 14 patients were treated with dacarbazine (DTIC) 1,200 mg/m2 as a 20-min infusion every 3 weeks, and 8 patients received a combination of carboplatin 300 mg/m2 as a 1-hour infusion on days 1 and 2 and VP-16 300 mg/m2 as a 1-hour infusion on days 1 and 2 every 3 weeks. Results: Treatment with DTIC led to stable disease in 2 patients and progressive disease in 12 patients. The combination of carboplatin/VP-16 resulted in stable disease in 1 patient and progressive disease in 7 patients. Overall, no remission was seen in 22 patients. Conclusions: Although the number of patients treated by us was small, neither DTIC nor carboplatin/VP-16 seem to be effective salvage chemotherapy regimens in adult patients with advanced soft tissue sarcoma pretreated with doxorubicin/ifosfamide.