Vibrational circular dichroism of polypeptides. VI. polytyrosine α‐helical and random‐coil results
作者:
S. C. Yasui,
T. A. Keiderling,
期刊:
Biopolymers
(WILEY Available online 1986)
卷期:
Volume 25,
issue 1
页码: 5-15
ISSN:0006-3525
年代: 1986
DOI:10.1002/bip.360250103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractWe have measured the VCD of polytyrosine in the amide I and II regions in dimethyl sulfoxide (DMSO) and in 80:20 mixtures of DMSO with trifluoroethanol, trifluoroacetic acid (TFA), and dichloroacetic acid and in 50:50 mixtures of DMSO and trimethyl phosphate (TMP). Additionally, VCD was obtained for deuterated polytyrosine in DMSO and DMSO:D2O, DMSO:TFA(d1), and DMSO:TMP mixtures as before. Amide A VCD was obtained in DMSO and DMSO:TMP mixtures. In the pure solvent, VCD of an opposite sign was seen as compared with that seen in the mixtures. The latter were characteristic in sign pattern and shape of right‐handed α‐helices for poly(L‐tyrosine). The pure polytyrosine:DMSO results are similar to those of polylysine:D2O at neutral pH and poly(β‐benzyl‐aspartate) in DMSO and may be characteristic of rand
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