Inactivation of atrial natriuretic factor in blood
作者:
Anthony T. Veress,
Chee K. Chong,
Harald Sonnenberg,
期刊:
Canadian Journal of Physiology and Pharmacology
(NRC Available online 1985)
卷期:
Volume 63,
issue 12
页码: 1615-1617
ISSN:0008-4212
年代: 1985
DOI:10.1139/y85-267
出版商: NRC Research Press
数据来源: NRC
摘要:
Tissue extracts of rat heart atria contain a family of peptides with natriuretic and vasorelaxant properties. It has been shown by others that inactivation of this atrial natriuretic factor may involve endogenous peptidases. The present experiments demonstrate that incubation in blood in vitro reduces the natriuretic activity of the factor. Specifically, inactivation was associated with a white cell/platelet fraction, indicating that these blood elements may play a physiological role in the metabolism of this new putative hormone.
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