Early Development of the Otocyst in an Exencephalic Mutant of the Mouse
作者:
Doris B. Wilson,
期刊:
Cells Tissues Organs
(Karger Available online 1983)
卷期:
Volume 117,
issue 3
页码: 217-224
ISSN:1422-6405
年代: 1983
DOI:10.1159/000145790
出版商: S. Karger AG
关键词: Otocyst;Exencephaly;Mouse embryo;Scanning-electron microscopy
数据来源: Karger
摘要:
Development of the otic anlage was studied by means of scanning electron microscopy in exencephalic loop-tail (Lp/Lp)embryos and in their normal (+/+; Lp/+)littermates at 8.5–9.5 days of gestation. In the abnormal embryos, the cells of the otic pit lack the rounded prominent surfaces and dense arrangement of microvilli which characterize the normal otic pit, and the overall configuration of the otic anlage is also distorted. The relatively early manifestation of abnormalities in the otic anlage of this mutant suggests that the defective neural tube may exert an influence as early as the otic placode stage, or that a common factor may simultaneously affect both otic and neural tube development in this mutan
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