A readily releasable pool of single inhibitory boutons in culture
作者:
Sergej Kirischuk,
Rosemarie Grantyn,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 17
页码: 3709-3713
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: GABAergic synaptic transmission;IPSC;Presynaptic vesicle;Readily releasable pool;RH414
数据来源: OVID
摘要:
The number of presynaptic vesicles that are immediately available for release, the readily releasable pool (RRP), is a strong determinant of synaptic strength and plasticity. The properties of the RRP in individual GABAergic synapses were examined in superior colliculus cultures. The RRP was depleted by high frequency trains and cumulative evoked IPSC amplitudes (CA) were calculated. The amplitude of monoquantal responses (q) was determined on the basis of mlPSC histograms. On average, the RRP, defined as CA/q, comprised about 10 vesicles. About 60% of the RRP could be released by a single stimulus. After depletion, the RRP was replenished with a time constant of about 14 s. These data provide information for further studies on the capacity of individual inhibitory synapses to modulate sensory information transfer.
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