Carbocyclic Ring Closure of an Aminodeoxy HEX-5-Enopyranoside
作者:
Mária Mádi-Puskás,
István Pelyvas,
Rezsö Bognár,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1985)
卷期:
Volume 4,
issue 3
页码: 323-331
ISSN:0732-8303
年代: 1985
DOI:10.1080/07328308508070183
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Ferrier's intramolecular carbocyclic ring closure reaction of methyl 3,4-di-O-acetyl-2-benzoyl-amino-2,6-dideoxy-α-O-xylo-hex-5-enopyranoside (2) led to 2L-2,4,513-2,3-di-O-acetyl-4-benzoylamino-5-hydroxy-cyclohexanone (4). Upon acetylation compound4underwent B-elimination to give the conjugated enone5. The convenient preparation of these highly functionalized aminocyclohexanones offers an efficient route to monoamino- or 1,4-diaminocyclitol-type aminoglycoside antibiotic aglycones, starting from 2-amino-2-deoxy-O-glucose.
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