The Nature of Intracrine Peptide Hormone Action
作者:
Richard Re,
期刊:
Hypertension
(OVID Available online 1999)
卷期:
Volume 34,
issue 4, Part 1
页码: 534-538
ISSN:0194-911X
年代: 1999
出版商: OVID
关键词: intracrine;peptides;nucleus;memory;differentiation
数据来源: OVID
摘要:
Current theory holds that peptide hormone action results from hormone binding to cell-surface receptors, with the generation of intracellular second messengers. However, a growing body of evidence suggests that intracellular peptide hormone, either internalized or synthesized in situ, can exert physiologically relevant effects. These effects are diverse and poorly understood. I propose that such intracrine action can serve to modulate cellular function over time and thereby play a role in biological memory of various sorts, in the maintenance of hormonal responsiveness, and in cellular differentiation.
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