Induction of Theophylline Metabolism by Pentobarbital
作者:
R. Dahlqvist,
E. Steiner,
Y. Koike,
C. von Bahr,
M. Lind,
B. Billing,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 4
页码: 408-410
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Theophylline;Pentobarbital;Drug interaction;Drug metabolism.
数据来源: OVID
摘要:
Summary:Theophylline concentrations in plasma and urine were determined during maintenance treatment in nine healthy volunteers during one dosage interval before and after 10 days of simultaneous treatment with pentobarbital (100 mg each night). During the pentobarbital period, total plasma clearance of theophylline increased by 40% (range −4‐79%), whereas renal clearance remained unchanged. It is concluded that therapeutic doses of pentobarbital induce the metabolism of theophylline with marked interindividual variation.
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