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Arterial and Venous Plasma Levels of Bupivacaine Following Epidural and Intercostal Nerve Blocks

 

作者: Daniel,   Moore Laurence,   Mather Phillip,   Bridenbaugh L.,   Bridenbaugh Robert,   Balfour Donald,   Lysons William,  

 

期刊: Anesthesiology  （OVID Available online 1976）
卷期: Volume 45, issue 1  

页码: 39-45

 

ISSN:0003-3022

 

年代: 1976

 

出版商: OVID

 

关键词: Anesthetics;local;bupivacaine;Anesthetic techniques;peridural;Anesthetic techniques;regional;intercostals

 

数据来源: OVID

 

摘要:

Arterial and peripheral venous plasma levels of huptvacaine were determined in 30 patients following epidural anesthesia using 150 and 225 mg, as well as following intercostal nerve block with 400 mg. Arterial levels were consistently higher than levels in simultaneously sampled venous blood, and the highest levels occurred with bilateral intercostal nerve block. No evidence of systemic toxicity was observed. The results suggest that bupivacaine may have a wider margin of safety in man than is now stated.

 

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