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The Total Chemical Synthesis of Monocyte Chemotactic Protein‐1 (MCP‐1)

 

作者: Angus R. Brown,   Maryanne Covington,   Robert C. Newton,   Robert Ramage,   Patricia Welch,  

 

期刊: Journal of Peptide Science  （WILEY Available online 1996）
卷期: Volume 2, issue 1  

页码: 40-46

 

ISSN:1075-2617

 

年代: 1996

 

DOI:10.1002/psc.46.o

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Tetrabenzo[a,c,g,i]fluorenyl‐17‐methoxycarbonyl;Tbfmoc;peptide synthesis;solid‐phase synthesis;MCP‐1

 

数据来源: WILEY

 

摘要:

AbstractThe affinity‐based Nα‐amino protecting group tetrabenzo [a,c,g,i]fluorenyl‐17‐methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine‐containing protein (MCP‐1). The base‐labile Tbfmoc group can be removed under very mild conditions, which preserve the thiol‐con taining protein in the reduced state. Oxidative folding was then used to furnish the biologically active

 

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