Chronic Effects of Interleukin-1 on Hypothalamus, Pituitary and Adrenal Glands in Rat
作者:
Yoshiyuki Naito,
Junichi Fukata,
Shigeo Nakaishi,
Yoshikatsu Nakai,
Yoshikatsu Hirai,
Sunao Tamai,
Kenjiro Mori,
Hiroo Imura,
期刊:
Neuroendocrinology
(Karger Available online 1990)
卷期:
Volume 51,
issue 6
页码: 637-641
ISSN:0028-3835
年代: 1990
DOI:10.1159/000125404
出版商: S. Karger AG
关键词: Interleukin-1;Adrenocorticotropic hormone;Corticotropin-releasing hormone
数据来源: Karger
摘要:
To assess the chronic effects of interleukin-1 (IL-1) and IL-2 on the hypothalamo-pituitary-adrenal axis in vivo, we administered recombinant human (rh) IL-1α, rhIL-1β or rhIL-2 (2.0 µg/day) repetitively to adult male rats for 10 days. In rhlL-1β-treated rats, adrenocorticotropic hormone-like immunoreactivity (ACTH-LI) of the anterior pituitary appeared to increase first on day 3 followed by an increase of corticotropin-releasing hormone (CRH)-LI both in the hypothalamus and in the adrenal gland after day 7. At the end of the 10-day treatment, wet weights of the adrenal glands of rhIL-1β-treated rats increased significantly compared with those of control rats. Plasma ACTH levels in rhIL-1 β-treated rats at the sampling time continued to be elevated throughout the experimental period. Under the same experimental design, rhIL-1α increased plasma ACTH levels at the sampling time without changes in adrenal weight or in the peptide contents investigated. The same amount of rhIL-2 had no effect on these measured variables during the 10-day treatment. These data indicate that the repetitive administration of IL-1β resulted in chronic effects in the hypothalamo pituitary-adrenal axis to increase the activities in these organs during the treatment and, moreover, IL-1 possibly has a positive direct effect on the CRH-containing cells in the adrenal
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