SummaryThree groups of 22 patients each were given oral hygiene nursing care using a standard procedure and using three different oral hygiene agent for each group—Milk of Magnesia substrate, Alkaline Aromatic Mouth Wash, or Hydrogen Peroxide (half strength of the three percent solution). Direction and degree of change were determined. While the smallness of the sample must be kept in mind, findings indicated that improvement occurred more frequently among patients in groups using Hydrogen Peroxide or Milk of Magnesia, although a greater degree of improvement was noted with the use of the former agent. Hydrogen Peroxide was more effective among patients over 50 years of age, while Milk of Magnesia was better for those under this age. Route of nutrition was seen to affect improvement, while route of respiration did not, regardless of the agent used. While patients did not seem to have a preference, nurses preferred the use of Milk of Magnesia as the oral hygiene agent.