Systemic and Neuropathologic Effects of E. coli Endotoxin in Neonatal Dogs
作者:
RICHARD YOUNG,
SUSAN YAGEL,
JAVAD TOWFIGHI,
期刊:
Pediatric Research
(OVID Available online 1983)
卷期:
Volume 17,
issue 5
页码: 349-353
ISSN:0031-3998
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
The acute systemic and neuropathologic effects ofE. coliendotoxin were determined in neonatal dogs. Administration of sublethal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter.
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