A gross reduction in chiasma formation during meiotic prophase and a defective DNA repair mechanism associated with a case of human male infertility
作者:
P.L. Pearson,
J.D. Ellis,
H.J. Evans,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1970)
卷期:
Volume 9,
issue 6
页码: 460-467
ISSN:1424-8581
年代: 1970
DOI:10.1159/000130115
出版商: S. Karger AG
数据来源: Karger
摘要:
Meiotic and histological studies have been carried out on testicular biopsies from an azoospermic human male who exhibited normal secondary sex characteristics. A failure in the formation of chiasmata during the first meiotic prophase resulted in a breakdown of the subsequent meiotic and spermatogenic processes. The few spermatozoa formed exhibited a range of DNA contents consistent with a random orientation and movement of the meiotic chromosomes. Radiation studies carried out on peripheral lymphocytes demonstrated that the patient had a reduced facility for chromosomal DNA repair. It is suggested that this defect gives an explanation for the failure of chiasma formation since chiasma formation probably involves a breakage, crossingover and repair of chromosomal DNA during the first meiotic prophase.
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