Nociceptin fails to affect heroin self‐administration in the rat
作者:
John Walker,
Mariarosa Spina,
Lars Terenius,
George Koob,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2243-2247
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Anti-opioid;Heroin;Nociceptin;Opioid;Orphanin FQ;Self-administration;Rat
数据来源: OVID
摘要:
THE recently isolated peptide nociceptin has a primary structure similar to that of opioid peptides. Early functional studies suggested that it may act in opposition to opioid systems. To determine whether nociceptin influences the rewarding properties of heroin, nociceptin was given intracerebroventricularly (i.c.v.) to rats trained to self-administer heroin. Rats (n= 8) were given doeses of 0.01 μg, 0.1 μg 1.0 μg and 10.0 μg in a Latin square design. None of the doses significantly affected heroin self-administration rates compared to vehicle. The highest dose of nociceptin used inhibited spontaneous locomotor activity, evidence that the peptide retained its biological activity after i.c.v. infusion. These studies suggest that nociceptin does not affect the rewarding value of heroin.
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