Eradication of Palpable Intradermal Murine Bladder Tumors by Systemic Interleukin‐2 and Cyclophosphamide in C3H Mice
作者:
Kan-ei Lee,
Robert O'Donnell,
Diana Marquis,
Abraham Cockett,
期刊:
Journal of Biological Response Modifiers
(OVID Available online 1988)
卷期:
Volume 7,
issue 1
页码: 32-42
ISSN:0732-6580
年代: 1988
出版商: OVID
关键词: Interleukin-2;Cyclophosphamide;Intradermal tumor
数据来源: OVID
摘要:
The effect of cyclophosphamide on interleukin-2 (IL-2) therapy was investigated using the intradermal MBT-2 tumor in C3H mice. Human recombinant IL-2 (Biogen) was given intraperitoneally at doses ranging from 5,000 to 30,000 U, three times a day for 5 or II-13 consecutive days beginning on day 10 after tumor implantation. When IL 2 was given alone, mice could not tolerate >5 days of 5,000 U IL 2/injection: Administration of 10,000 and 15,000 U/injection of IL-2 for 5 days resulted in 64% (9 of 14) and 100% (14 of 14) mortality, respectively. Chemotherapeutic agents (cisplatin at 6 mg/kg or JM-8 75 mg/kg) and daily administration of cortisone acetate (75 mg/kg) partially protected mice from IL-2-induced toxic deaths. Coadministration of mannitol showed no protective effect. The combination of IL-2 and CY at 75 or 100 mg/kg, however, dramatically reduced the mortality induced by IL-2 and made it possible to escalate the dose and long-term administration of IL-2. Combination administration of 75 mg/kg CY with 15,000 U/injection of IL-2 for 11–13 days caused tumor regressions and resulted in a 66% (8 of 12) cure rate.
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