Systemic absorption and systemic effects of ocularly administered dexmedetomidine in rabbits
作者:
MacdonaldEwen,
VartiainenJaana,
JäsbergKari,
VuorilehtoLauri,
SalonenJarmo S.,
UrttiArto,
期刊:
Current Eye Research
(Taylor Available online 1993)
卷期:
Volume 12,
issue 5
页码: 451-460
ISSN:0271-3683
年代: 1993
DOI:10.3109/02713689309024627
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Dexmedetomidine is a selective alpha2- adrenoceptor agonist which has previously been shown to reduce the ocular pressure of normotensive rabbits as well as those with pressures artificially elevated by laser irradiation. In this study instillation of an equivalent hypotensive dose (12.5μg) did not cause changes in heart rate, blood pressure, blood glucose or plasma catecholamine content even though dexmedetomidine could be detected in plasma. However, this dose given intravenously (i.v.) was also without effect. Higher ocular doses resulted in equivalent bradycardia and changes in blood glucose levels as when the dose was given i.v. These two parameters proved to be most sensitive indicators of systemic alpha2-agonism, blood pressure did not change and plasma catecholamine levels were too low to be reliably assayed. It is concluded that when hypotensive doses of dexmedetomidine are instilled into the eye, intraocular concentrations are sufficiently high to exert pharmacological effects. As it is absorbed into the general circulation, it is diluted such that its systemic effects are minimal.
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