Endothelial Cells of Hematopoietic Origin Make a Significant Contribution to Adult Blood Vessel Formation
作者:
Jeffrey Crosby,
Wolfgang Kaminski,
Gina Schatteman,
Paul Martin,
Elaine Raines,
Ron Seifert,
Daniel Bowen-Pope,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2000)
卷期:
Volume 87,
issue 9
页码: 728-730
ISSN:0009-7330
年代: 2000
出版商: OVID
关键词: hematopoietic stem cell;angiogenesis;endothelial cell
数据来源: OVID
摘要:
Granulation tissue formation is an example of new tissue development in an adult. Its rich vascular network has been thought to derive via angiogenic sprouting and extension of preexisting vessels from the surrounding tissue. The possibility that circulating cells of hematopoietic origin can differentiate into vascular endothelial cells (ECs) in areas of vascular remodeling has recently gained credibility. However, no quantitative data have placed the magnitude of this contribution into a physiological perspective. We have used hematopoietic chimeras to determine that 0.2% to 1.4% of ECs in vessels in control tissues derived from hematopoietic progenitors during the 4 months after irradiation and hematopoietic recovery. By contrast, 8.3% to 11.2% of ECs in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulating hematopoietic progenitors. This recruitment of circulating progenitors to newly forming vessels would be difficult to observe in standard histological studies, but it is large enough to be encouraging for attempts to manipulate this contribution for therapeutic gain.
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