AbstractSynchronized bursts of efferent sympathetic impulses, appearing either spontaneously or triggered by various peripheral stimuli, were recorded with microelectrodes inserted percutaneously into skin nerve fascicles in alert, adult subjects. The signals were abolished by sympathetic ganglion blocking agents and by Lidocaine nerve blocks proximal to the recording site. Many of the sympathetic discharges were succeeded by skin resistance changes and plethysmographic vasoconstrictor responses within the innervation zone of the fascicle impaled. The sympathetic activity was not pulse synchronous as in muscle nerves and the spontaneous sympathetic volleys occurred largely independently of spontaneous blood pressure variations, indicating a relative lack of baroreflex control of the vasoconstrictor outflow to the skin. A loose coupling was observed, however, between the resting respiratory rhythm and the spontaneous sympathetic bursts in the skin nerves.