Cytokeratin Fragment 19 and Squamous Cell Carcinoma Antigen for Early Prediction of Recurrence of Squamous Cell Lung Carcinoma
作者:
Shung-Shung Sun,
Jih-Fang Hsieh,
Shih-Chuan Tsai,
Yung-Jen Ho,
Jong-Kang Lee,
Chia-Hung Kao,
期刊:
American Journal of Clinical Oncology: Cancer Clinical Trials
(OVID Available online 2000)
卷期:
Volume 23,
issue 3
页码: 241-243
ISSN:0277-3732
年代: 2000
出版商: OVID
关键词: Cytokeratin 19 fragment (CYFRA 21-1);Squamous cell carcinoma antigen;Lung cancer.
数据来源: OVID
摘要:
Sixty patients with squamous cell carcinoma (SCC) of the lung, including 25 cases with recurrence and 35 cases without recurrence 1 year after operation, were enrolled in this study. The serial serum levels of cytokeratin fragment 19 (CYFRA 21-1) and SCC antigen were measured before operation and 1 week, 1 month, 3 months, 6 months, 9 months, and 12 months after operation for early detection of recurrence. The results revealed that 1) mean serum values of CYFRA 21-1 were significantly higher at early and any times after operation in 25 patients with recurrent SCC when compared with 35 patients without recurrent SCC; and 2) mean serum values of SCC antigen were significantly higher until 9 and 12 months after operation, in 25 patients with recurrent SCC when compared with 35 patients without recurrent SCC. We conclude that CYFRA 21-1 is a better marker than SCC antigen for early prediction of SCC recurrence in the lung.
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