The expeditious and safe transport of the seriously ill neonate begins with the doctors and nurses at the referring facilities. They have the responsibility for the initial stabilization and play an important role in the future outcome of the seriously ill neonate. Nurses need to be able to identify, assess, and intervene when congenital or physiologic abnormalities occur in the neonate. They can facilitate and expedite the transport process with the knowledge of what is needed in preparation of the transfer of an infant. In addition, they can help assess and support the family of the transferred neonate during a period of significant stress.