Simulation of Calorimetric Melting Processes—A Useful Tool for Enantiomeric Purity Determination
作者:
Rainer Stosch,
MartinMichael Welzel,
Sigurd Bauerecker,
Heiko Karlcammenga,
期刊:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
(Taylor Available online 1998)
卷期:
Volume 312,
issue 1
页码: 285-295
ISSN:1058-725X
年代: 1998
DOI:10.1080/10587259808042447
出版商: Taylor & Francis Group
关键词: Enantiomeric purity;phase diagram;calorimetry;simulation;DSC
数据来源: Taylor
摘要:
Simulation of calorimetric fusion curves was introduced as a new technique in calorimetric purity analysis and has now been tested for its applicability to enantiomeric purity determination. The system investigated was the enantiomeric pair (S)-(+)-1-Indanol/(R)-(-)-1-Indanol. The racemic form of this system either exists as a conglomerate or as a racemic compound. The binary fusion diagrams of both forms of enantiomeric mixtures were built up from melting investigations and were compared with calculations. The results obtained show that the simulation method is suitable to determine enantiomeric purities by an accuracy of better than 10% within a concentration range 80… 100%eewhich is the important range for purity analysis.
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