Innervation of the Human Uterine Artery and Contractile Responses to Neuropeptides
作者:
Rickard Ekesbo,
Per Alm,
Per Ekström,
Lena-Maria Lundberg,
Mats Åkerlund,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1991)
卷期:
Volume 31,
issue 1
页码: 30-36
ISSN:0378-7346
年代: 1991
DOI:10.1159/000293096
出版商: S. Karger AG
关键词: Uterine artery;Neutrotransmitters;Neuropeptides;Immunohistochemistry;Contractile effects
数据来源: Karger
摘要:
The intrinsic innervation of the human uterine artery was investigated histochemically, and the motor responses to some of the demonstrated peptides and other humoral factors were studied on isolated vascular preparations. There were nerves with specific immunoreactivities for tyrosine hydroxylase, dopamine β-hydroxylase, neuropeptide-Y (NPY), vasoactive intestinal peptide (VIP) and peptide histidine methionine, and enzymatic reactivity for acetylcholine esterase. The most effective stimulator of smooth muscle contractility was arginine vasopressin followed in order by oxytocin, noradrenaline together with NPY, noradrenaline alone and dopamine. No effect was seen with acetylcholine and tyrosine, and VIP caused inconsistent relaxation of contractile activity induced by PGF2α. These results suggest that the uterine blood flow is regulated by complex interactions of factors, some occurring in nerve terminals and some being circulating humoral factors.
点击下载:
PDF
(2776KB)
返 回