A Controlled Endoscopic Study Comparing the Toxic Effects of Sulindac, Naproxen, Aspirin, and Placebo on the Gastric Mucosa of Healthy Volunteers
作者:
FRANK L. LANZA,
ROBERT S. NELSON,
MARY FRANCES RACK,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1984)
卷期:
Volume 24,
issue 2‐3
页码: 89-95
ISSN:0091-2700
年代: 1984
DOI:10.1002/j.1552-4604.1984.tb02770.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract:Sixty volunteers were endoscopically evaluated to compare gastric mucosal injury following oral administration of sulindac, naproxen, aspirin, or placebo for two consecutive seven‐day periods. A single‐blind technique was utilized wherein the endoscopist was unaware which drug each volunteer had received. The following dosages were employed for the two study periods: sulindac, 150 and 200 mg, b.i.d., naproxen, 250 and 375 mg, b.i.d., and aspirin, 650 and 975 mg, q.i.d. The only subject who developed a frank ulcer with mucosal bleeding was in the sulindac group, however volunteers taking sulindac demonstrated statistically less significant mucosal injury on endoscopic examination than those receiving naproxen or aspi
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