Studies on the Synthesis of Antibiotic Conjugates with Chitosan
作者:
期刊:
Biotechnology & Biotechnological Equipment
(Taylor Available online 1997)
卷期:
Volume 11,
issue 1-2
页码: 30-33
ISSN:1310-2818
年代: 1997
DOI:10.1080/13102818.1997.10818926
出版商: Taylor & Francis
数据来源: Taylor
摘要:
Chitosan is stepwise treated with periodic acid, urea and formaldehyde and then introduced hydroxymethyl groups reacted with tetracycline and carminomycin. The conjugates obtained are fully soluble in dimethylformamide in contrast to the free chitosan. The conjugate of chitosan with tetracycline preserves almost fully the antibacterial activity of the free tetracycline. An enhenced antitumour activity and decreased toxicity of carminomycin are detected after its conjugation with chitosan.
点击下载:
PDF (232KB)
返 回