Mutagenicity and genotoxicity of sorbic acid-amine reaction products
作者:
Carine Ferrand,
FranÇoise Marc,
Pierre Fritsch,
Pierrette Cassand,
Georges Saint de Blanquat,
期刊:
Food Additives & Contaminants
(Taylor Available online 2000)
卷期:
Volume 17,
issue 11
页码: 895-901
ISSN:0265-203X
年代: 2000
DOI:10.1080/026520300750038063
出版商: Taylor & Francis Group
关键词: Sorbic Acid Amines Reaction Products Salmonella Typhimurium 3d Test
数据来源: Taylor
摘要:
Sorbic acid (E200) and its salts (potassium and calcium sorbate: E202 and E203) are allowed for use as preservatives in numerous processed foods. Sorbic acid had a conjugated system of double bonds which makes it susceptible to nucleophilic attack, sometimes giving mutagenic products. Under conditions typical of food processing (50-80°C), we analysed the cyclic derivatives resulting from a double addition reaction between sorbic acid and various amines. Mutagenesis studies, involving Ames' test and genotoxicity studies with HeLa cells and plasmid DNA, showed that none of the products studied presented either mutagenic or genotoxic activities.
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