Lower density of A1 adenosine receptors in nucleus reticularis thalami in rats with genetic absence epilepsy
作者:
Antigoni Ekonomou,
Fevronia Angelatou,
Marguerite Vergnes,
George Kostopoulos,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2135-2140
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: A1 adenosine receptors;Absence epilepsy;GAERS;Rat brain
数据来源: OVID
摘要:
THE possible involvement of the adenosinergic modula-tory system in the pathogenesis of absence seizures was investigated in genetic absence epilepsy rats from Strasbourg (GAERS). Usin gin vitroquantitative autoradiography, the distribution of A1 adenosine receptors and adenosine uptake sites in the brain of GAERS was studied and compared to that of control animals. An area-specific lower density of A1 receptors (15% decrease) was detected in reticular (nRT) and anterior ventral (AV) thalamic nuclei as well as basal ganglia in the brains of GAERS animals compared with control animals. Since adenosine exerts an anti-oscillatory effect on the thalamic nuclei by suppressing (via A1 receptors) excitatory as well as inhibitory neurotransmitter release, the impairment in A1 receptor density seen here, especially in nRT, could be implicated in the thalamic rhythmicity underlying spike and wave discharges present in this absence epilepsy model.
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