Anti-Diabetogenic Effect of Fusidic Acid in Diabetes Prone Bb Rats
作者:
BuschardKarsten,
PedersenCharlotte,
HansenSusanne V.,
HagemanIda,
AaenKim,
BendtzenKlaus,
期刊:
Autoimmunity
(Taylor Available online 1992)
卷期:
Volume 14,
issue 2
页码: 101-104
ISSN:0891-6934
年代: 1992
DOI:10.3109/08916939209083127
出版商: Taylor&Francis
关键词: Fusidic acid;insulin dependent diabetes mellitus;BB rats;insulitis
数据来源: Taylor
摘要:
Fusidic acid and its sodium salt (fusidin) are anti-staphylococcal drugs.In vitrostudies have shown that they prevent the lymphocyte co-stimulatory activities of the cytokines IL-1 and IL-6 in a manner similar to that of cyclosporin A. and prevent the inhibitory effect of IL-1 on glucose-induced insulin production. As IL-1 and IL-6 are thought to play a role in the pathogenesis of Type 1 diabetes, the aim of this study was to investigate whether fusidin could influence the disease incidence of the spontaneously diabetic BB rat model. Accordingly, a group of 50 BB rats receiving fusidin dissolved in their drinking water were compared to a control group of 55 rats over a period of 200 days. The incidence of diabetes was found to be 52% in the experimental group and 71% in the control group (R<0.05). The degree of insulitis and the number of islets at histological examination were similar among the non-diabetic animals whereas the diabetic fusidin-treated animals showed a higher degree of islet preservation than the diabetic control rats. The results are highly indicative of an anti-diabetogenic effect of fusidin.
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