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Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine

 

作者: ChristopherN. Frantz,   H. V. Mailing,  

 

期刊: Journal of Toxicology and Environmental Health  （Taylor Available online 1976）
卷期: Volume 2, issue 1  

页码: 179-187

 

ISSN:0098-4108

 

年代: 1976

 

DOI:10.1080/15287397609529425

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Many chemicals are not mutagenic per se, but when metabolized by mammalian tissues yield mutagenic products. Dimethylnitrosamine (DMN) is such a promutagen. It has no effect on cell growth or mutant frequency when Incubated alone with L5178Y mouse lymphoma cells, but exerts both mutagenic and toxic effects when incubated in a microsome reaction mixture.

 

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