The Importance of Vasopressin in the Development and Maintenance of DOC‐Salt Hypertension in the Rat
作者:
JOAN CROFTON,
LEONARD SHARE,
ROBERT SHADE,
WON LEE-KWON,
MAURICE MANNING,
WILBUR SAWYER,
期刊:
Hypertension
(OVID Available online 1979)
卷期:
Volume 1,
issue 1
页码: 31-38
ISSN:0194-911X
年代: 1979
出版商: OVID
关键词: vasopressin;DOC-salt hypertension;antidiuretic hormone Brattleboro rat;diabetes insipidus;vasopressin competitive inhibitor
数据来源: OVID
摘要:
SUMMARY Experiments were performed to determine the role of vasopressin in deoxycorticosterone (DOC)-salt hypertension. In order to determine if vasopressin is necessary for the development of DOC-salt hypertension, rats with hereditary diabetes insipidus (DI) and normal Long-Evans rats (LE) were unilaterally nephrectomized, treated with DOC Pivalate (30 mg/kg week) and given saline to drink for 8 weeks. A second group of DI rats were unilaterally nephrectomized, but received no treatment. Systolic blood pressure (SBP) increased 40 mm Hg in the LE group (p< 0.01) but failed to increase significantly in either DI group. Urinary excretion of vasopressin (UADHV) and SBP were measured in unilaterally nephrectomized LE rats treated with DOC and salt (DOC-LE), salt alone (NaCI-LE) and untreated rats (H.O-LE). The UADHV was elevated in DOC-LE (j> < 0.01) and NaCI-LE (p< 0.05) rats, but only the DOC-LE rats became hypertensive. Finally, the I.V. injection of analogs of vasopressin, which block its pressor but not antidluretic activity, lowered mean arterial blood pressure 27 ± 5 mm Hg in 11 conscious DOC-salt hypertensive rats. It is concluded that vasopressin plays a major role as a pressor agent in both the onset and maintenance of DOC-salt hypertension.
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