Correlation between Rsal Restriction Fragment Length Polymorphism and Electrophoretic Types of Human Placental Alkaline Phosphatase
作者:
G. Beckman,
L. Beckman,
E. Lundgren,
J.L. Millán,
C. Sikström,
期刊:
Human Heredity
(Karger Available online 1989)
卷期:
Volume 39,
issue 1
页码: 41-45
ISSN:0001-5652
年代: 1989
DOI:10.1159/000153830
出版商: S. Karger AG
关键词: Polymorphism;Gene structure;Population genetics;RFLP
数据来源: Karger
摘要:
Restriction fragment length polymorphism (RFLP) of human alkaline phosphatases was studied in a population sample from northern Sweden using a placental alkaline phosphatase (PLAP) cDNA probe. After digestion of human genomic DNA with Rsal the Southern blots showed DNA fragments most probably derived from three genes: PLAP, germ cell alkaline phosphatase (PLAP-like) and intestinal alkaline phosphatase. In agreement with a previous study, a two-allele polymorphism was found in PLAP with bands at 1.6 kilobases (A1) and 1.8 kilobases (A2). The gene frequencies of A1 and A2 were 0.46 and 0.54, respectively. There was a significant correlation between the Rsal RFLPs and electrophoretic types of PLAP; RSAI A2 showed an association with the ALP2Pallele of PLAP.
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