Decline of HIV antigen levels in cerebrospinal fluid during treatment with low‐dose zidovudine
作者:
Jan de Gans,
Joep Lange,
Mayke Derix,
Frank de Wolf,
Jan M. Eeftinck Schattenkerk,
Sven Danner,
Bram Ongerboer de Visser,
Paul Cload,
Jaap Goudsmit,
期刊:
AIDS
(OVID Available online 1988)
卷期:
Volume 2,
issue 1
页码: 37-40
ISSN:0269-9370
年代: 1988
出版商: OVID
关键词: HIV antigen;zidovudine;cerebrospinal fluid;AIDS
数据来源: OVID
摘要:
Six HIV-antigenaemic patients with AIDS or AIDS-related complex were studied to assess the effect of treatment with low-dose zidovudine (250 mg) in 6-hourly doses on HIV antigen (HIV-Ag) levels in cerebrospinal fluid (CSF). HIV-Ag was detected in CSF of three patients before treatment. These patients became CSF HIV-Ag-negative within 8 weeks of treatment. One initially CSF HIV-Ag-negative patient became strongly CSF HIV-Ag-positive during interruption of zidovudine treatment; CSF HIV-Ag disappeared again after treatment was restarted. None of our patients showed a significant neurological improvement during the study. These results show that low-dose zidovudine can suppress viral expression in CSF. Whether suppression of viral replication can prevent future HIV-related neurological disease remains to be investigated.
点击下载:
PDF
(318KB)
返 回