Kinetic Method of Tetracycline and Oxytetracycline Assay Using Spect-Rophotometric Measurements
作者:
M.Abdel-Hady Elsayed,
M.H. Barary,
H. Mahgoub,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 11
页码: 1357-1373
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066216
出版商: Taylor & Francis Group
关键词: tetracycline;oxytetracyoline;degradation rate;Kinetic method;powder and capsule assay
数据来源: Taylor
摘要:
A Kinetic method is based on the degradation rate of tetracycline (TC) or oxytetracycline (OTC) to their anhydro derivatives with subsequent spectrophotometric measurements. With optimized degradation rate parameters, calibration curves relating decrease in absorbance difference (of alkaline solution versus acid solution) as a funotion of concentration in a range of 0.8-4.0 mg% are linear with negligible interecept. The method is applicable for powder and capsule assays and gives results within the pharmacopoeial limits.
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