Estimation of direct runoff, peak discharge or hydrographs is often necessary in small to medium-sized ungauged basins. Different models are used in practice for these purposes, depending on the type of problem, the available data and the prevailing runoff mechanisms in the study basin. This paper discusses the applicability of the curve number procedure developed by the US Soil Conservation Service (SCS) to estimate direct runoff in basins characterized by small to gentle undulating slopes mainly covered with natural grasslands. Rainfall and runoff data measured in the Cañada de Los Chanchos basin in Uruguay is used to fit the curve numbers and to analyse the antecedent soil moisture condition proposed by the SCS.