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Fructose‐1, 6‐diphosphate as anin vitroandin vivoanti‐alcohol agent in the rat

 

作者: L. Galzigna,   M. Bianchi,   V. Rizzoli,   R. Scuri,   P. Giannetti,   A. Paesano,  

 

期刊: Cell Biochemistry and Function  （WILEY Available online 1990）
卷期: Volume 8, issue 1  

页码: 39-47

 

ISSN:0263-6484

 

年代: 1990

 

DOI:10.1002/cbf.290080107

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Fructose‐1, 6‐diphosphate (FDP);heart slices;GABA‐receptors;Ca++entry;Cl−up‐take;gastric ulcers;serum transaminases;diuresis;narcosis;dependence and withdrawal symptoms

 

数据来源: WILEY

 

摘要:

AbstractFructose‐1, 6‐diphosphate (FDP) decreases the effect of ethanol on Ca++entry and inhibits the ethanol‐stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol‐stimulated [36Cl−]‐uptake by rat brain microvesicles and affects the isolated GABA‐receptor in a way opposite to that of ethanol. Thein vivoeffects of FDP include a dose‐dependent decrease in ethanol‐induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also co

 

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