Most HIV‐1 genetic subtypes have entered Sweden
作者:
Annette Alaeus,
Thomas Leitner,
Knut Lidman,
Jan Albert,
期刊:
AIDS
(OVID Available online 1997)
卷期:
Volume 11,
issue 2
页码: 199-202
ISSN:0269-9370
年代: 1997
出版商: OVID
关键词: HIV-1;molecular epidemiology;genetic subtype;clade;Sweden;V3
数据来源: OVID
摘要:
Objective:The aim of this study was to document which genetic subtypes of HIV-1 have entered Sweden and to study transmission patterns of these virus variants.Patients:All HIV-1-infected individuals at Danderyds Hospital, Stockholm, Sweden, who were suspected of carrying a virus of African origin were prospectively included in the study. The study subjects originated from 15 different African countries.Methods:The V3 domain of the HIV-1 envelope was directly sequenced from uncultured peripheral blood mononuclear cells from 75 individuals included in the study. Phylogenetic analyses were used to determine genetic subtype and to study transmission patterns.Results:The virus strains carried by the study subjects belonged to six established subtypes of HIV-1 (27A, 4B, 18C, 18D, 2G, 2H). Two individuals from Zaire carried a subtype, which had not been classified previously, provisionally named subtype J. Eleven transmissions of non-subtype B strains in Sweden were documented.Conclusions:This study shows that most genetic HIV-1 subtypes have entered Sweden despite the relatively low prevalence of HIV infection in the country. Thus, the complete dominance of subtype-B infections which was seen during the early phase of the HIV-1 epidemic in Europe and the US has been broken in Sweden.
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