Lipid peroxidation in experimental uveitis: Sequential studies
作者:
GotoHiroshi,
ShuangGuey,
ChenFen,
KristevaMichaela,
Sevanian1Alex,
RaoNarsing A.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 6
页码: 489-499
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209001805
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Previously we have detected the occurrence of retinal lipid peroxidation initiated by phagocyte-derived oxygen radicals in experimental autoimmune uveitis (EAU). In the current studies, the confirmation of inflammation-mediated lipid peroxidation was proceeded further to include measurement of multiple parameters, including conjugated dienes, ketodienes, thiobarbituric acid reactive substances and fluorescent chromolipids. The assay for myeloperoxidase, a measure for the number of polymorphonuclear leukocytes in the inflammatory sites was also carried out. The levels of all these parameters were followed through the course of EAU development. The sequential evaluation of histologic changes using both light and electron microscopy was also carried out and the results were correlated with lipid peroxidation indices. These data suggest that the retinal lipid peroxidation plays a causative role in the subsequent retinal degeneration.
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