Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash
作者:
P. K. Srivastava,
U. K. Misra,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 18,
issue 3
页码: 471-481
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530886
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The effect of intratracheal administration of fly ash has been studied on lung micro‐somal and lung surfactant phosphatidylcholine (PC) metabolism in rats using [methyl‐14C]choline and [methyl‐14C]methionine. Fly‐ash administration significantly increased total phospholipids, PC, phosphatidylethanolamine (PE), and phosphati‐dylglycerol (PC) of lung surfactant. Fly‐ash administration stimulated the formation of lung microsomal PC (as measured by the incorporation of labeled precursors) both by the cytidine 5'‐diphosphate (CDP)‐choline pathway and by the N‐methylation pathway, but this stimulation was fourfold higher in the latter case and only twofold higher in the former as compared to the control. Likewise, the secretion of PC formed by the N‐methylation pathway was sixfold higher as compared to the control whereas secretion of PC formed by the CDP‐choline pathway was only threefold higher as compared to the control. Fly‐ash administration further increased total saturation and decreased unsaturation in PC, PE, and lysophosphatidylcholine (LPC) of lung and in PC, PE, LPC, and PC of lung surfactant as compared to the controls.
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