Glucose Biosensor Based on Oxygen Electrode Part IV: In Vivo Evaluation of the Rechargeable Glucose Sensor
作者:
Saipeng Yang,
Ceeyavash Salehi,
Plamen Atanasov,
Ebtisam Wilkins,
期刊:
Analytical Letters
(Taylor Available online 1996)
卷期:
Volume 29,
issue 7
页码: 1081-1097
ISSN:0003-2719
年代: 1996
DOI:10.1080/00032719608001460
出版商: Taylor & Francis Group
关键词: Glucose biosensor;in vivo evaluation;rechargeable sensor
数据来源: Taylor
摘要:
A glucose monitoring system consisting of a pair of amperometric sensors: a glucose biosensor based on oxygen electrode and an oxygen sensor, two miniature potentiostats, an instrumentation amplifier and a data logger has been developed. The glucose sensor has linear response to the glucose concentration invitroat 37°C up to 26 mM (480 mg/dL) in the phosphate buffer solution (pH 7.4), and linear range up to 21 mM (380 mg/dL) in undiluted bovine plasma. The system was evaluatedin vivowith the sensors subcutaneously implanted in healthy mongrel dogs. During the implantation the system output was continuously recorded. The results of short-term subcutaneous implantation of the integrated system demonstrated good agreement between the glucose concentration measured by the biosensor and that obtained using standard glucose determination methods. The delay-time between the tissue glucose level (measured by the biosensor) and the blood glucose level (obtained by standard methodology) was 3 to 10 minutes. During the chronic implantation the biosensor was refilledin vivo. Rejuvenation of the sensor response after refilling was observed demonstrating the potential of such sensors for long-term implantation.
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