首页   按字顺浏览 期刊浏览 卷期浏览 Free Radicals as Mediators of Tissue Injury and Disease
Free Radicals as Mediators of Tissue Injury and Disease

 

作者: KehrerJames P.,  

 

期刊: Critical Reviews in Toxicology  (Taylor Available online 1993)
卷期: Volume 23, issue 1  

页码: 21-48

 

ISSN:1040-8444

 

年代: 1993

 

DOI:10.3109/10408449309104073

 

出版商: Taylor&Francis

 

关键词: free radicals;oxygen radicals;inflammation;rheumatoid arthritis;atherosclerosis;cancer;reperfusion injury;oxygen toxicity;quinines;metal chelates;nitro compounds;bipyridilium compounds

 

数据来源: Taylor

 

摘要:

AbstractA radical is any molecule that contains one or more unpaired electrons. Radicals are normally generated in many metabolic pathways. Some of these radicals can exist in a free form and subsequently interact with various tissue components resulting in dysfunction. The potential role of oxygen- or xenobiotic-derived free radicals in the pathology of several human diseases has stimulated extensive research linking the toxicity of numerous xenobiotics and disease processes to a free radical mechanism. However, because free radical-mediated changes are pervasive and often poorly understood, the question of whether such species are a major cause of tissue injury and human disease remains equivocal. This review discusses cellular sources of various radical species and their reactions with vital cellular constituents. Examples of purported free radical-mediated disorders are discussed in detail to provide insights into the controversy over whether free radicals are important mediators of tissue injury.

 

点击下载:  PDF (2377KB)



返 回