Pharmacokinetics of Single Oral Doses of Nortriptyline in Depressed Elderly Hospital Patients and Young Healthy Volunteers
作者:
S. Dawling,
P. Crome,
R. Braithwaite,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1980)
卷期:
Volume 5,
issue 4
页码: 394-401
ISSN:0312-5963
年代: 1980
出版商: ADIS
数据来源: ADIS
摘要:
A single oral dose of 75mg nortriptyline was given to a group of 20 depressed elderly patients in hospital. Subsequent plasma nortriptyline concentrations were used to calculate the half-life and clearance of the drug. These measurements were compared with those made previously in 17 healthy young volunteer subjects.Plasma nortriptyline half-life was longer and clearance slower (p < 0.002) in the elderly group than in the volunteers. There was no correlation of age with either of these parameters within the 2 groups, and no differences in nortriptyline pharmacokinetics could be detected between the male and female volunteer subjects. The possible reasons for these findings and their clinical consequences are discussed.
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