Effect of Antihypertensive Drugs on Catechol-O-Methyltransferase and Monoamine Oxidase Activity in Human Term Placental Explants
作者:
E.R. Barnea,
H. Fakih,
G. Oelsner,
S. Walner,
A.H. DeCherney,
F. Naftolin,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1986)
卷期:
Volume 21,
issue 3
页码: 124-130
ISSN:0378-7346
年代: 1986
DOI:10.1159/000298941
出版商: S. Karger AG
关键词: Antihypertensive drugs;Placenta;Catechol-O-methyltransferase;Monoamine oxidase
数据来源: Karger
摘要:
The effects of therapeutic concentrations of antihypertensive drugs on catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) activities in term placental explants were studied. The enzyme activities were measured in tissue fractions using radioen-zymatic techniques. At 6 h the incubation COMT activity increased significantly following exposure to verapamil and hydralazine, while exposure to alpha methyldopa caused a significant suppression of the enzyme. At 24 h exposure to hydralazine significantly suppressed the COMT activity. By 6 h the MAO activity was significantly suppressed by verapamil. MgSO4 and propranolol had no effect on the activities of COMT and MAO at 6 and 24 h. These results suggest that COMT and MAO activities in the placenta can be modulated by antihypertensive drugs and, therefore, these drugs might affect local catechol metabolism.
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