Application of PMR Spectrometry in Pharmaceutical Analysis III. Assay of Carbamazepine
作者:
HamedM. El-fatatry,
HassanY. Aboul-enein,
EssamA. Lotfi,
期刊:
Analytical Letters
(Taylor Available online 1979)
卷期:
Volume 12,
issue 8
页码: 951-961
ISSN:0003-2719
年代: 1979
DOI:10.1080/00032717908059774
出版商: Taylor & Francis Group
关键词: PMR spectrometry;pharmaceutical analysis;assay of carbamazepine tablets (Tegretol®)
数据来源: Taylor
摘要:
Carbamazepine, a tricyclic antidepressant, has been assayed in its tablets (Tegretol ®) by the application of PMR spectrometry. The proposed method involves comparing the integral of the aromatic and olefinic protons of carbamazepine, in the range 6.60 -7.60 ppm, to that of the singlet of a known amount of hexamethylcyclotrisilazane (at 0.00 ppm) used as internal standard. The method is simple, rapid and accurate. The average percent recovery, of carbamazepine from its tablets, is 96.88 ± 0.93. In addition, the PMR spectrum obtained helps in checking the identity and purity of the drug extracted from its pharmaceutical preparation.
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