Synthesis and15N NMR spectra of 1‐ and 4‐15N‐2,3,5‐trimethylpyrazines and their N‐oxides
作者:
Mikiko Maeda,
Chiseko Sakuma,
Shinji Kawachi,
Katsumi Tabei,
Ablikim Kerim,
Teruo Kurihara,
Akihiro Ohta,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1995)
卷期:
Volume 36,
issue 1
页码: 85-92
ISSN:0362-4803
年代: 1995
DOI:10.1002/jlcr.2580360111
出版商: John Wiley&Sons, Ltd.
关键词: synthesis;1‐15N‐2,3,5‐trimethylpyrazine;4‐15N‐2, 3, 5‐trimethylpyrazine;15N NMR
数据来源: WILEY
摘要:
Abstract4‐15N‐2,3,5‐Trimethylpyrazine (1) was synthesized by dechlorination of 4‐15N‐6‐chloro‐2, 3, 5‐trimethylpyrazine (5) the key intermediate, derived from15N‐DL‐alanine (3).1‐15N‐2,3,5‐Trimethylpyrazine (2) was prepared by decarboxylation of 1‐15N‐2, 3, 5‐trimethyl‐pyrazine‐6‐carboxylic acid (10) obtained by the Pummerer type rearrangement of 1‐15N‐tetramethylpyrazine 1‐oxide (1) followed by oxidation.1‐ And 4‐oxides and 1,4‐dioxides of the above15Ntrimethylpyrazines were also obtained by treatment with sodium perborate in acetic acid.15N NMR spectra of the compounds thus prepared were measured an
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